1. Medical ScienceA lentigo () (plural lentigines, ) is a small pigmented spot on the skin with a clearly defined edge, surrounded by normal-appearing skin. It is a harmless (benign) hyperplasia of melanocytes which is linear in its spread. This means the hyperplasia of melanocytes is restricted to the cell layer directly above the basement membrane of the epidermis where melanocytes normally reside. This is in contrast to the "nests" of multi-layer melanocytes found in moles (melanocytic nevi). Because of this characteristic feature, the adjective "lentiginous" is used to describe other skin lesions that similarly proliferate linearly within the basal cell layer. == Diagnosis == Conditions characterized by lentigines include: Lentigo simplex Solar lentigo (Liver spots) PUVA lentigines Ink spot lentigo LEOPARD syndrome Mucosal lentigines Multiple lentigines syndrome Moynahan syndrome Generalized lentiginosis Centrofacial lentiginosis Carney complex Inherited patterned lentiginosis in black persons Partial... from wikipedia.org